Food and Agricultural Industry Law
Rahim RahbarNouhi; Mohammad Reza Dehghani
Volume 2, Issue 2 , February 2025, , Pages 67-85
Abstract
Background and Objective: Marinol is actually the first cannabinoid drug approved by the US FDA in 1985. The approved use of this drug in reducing the side effects caused by chemotherapy of cancer patients such as anorexia, nausea, pain and vomiting, as well as its use in the treatment of weight loss ...
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Background and Objective: Marinol is actually the first cannabinoid drug approved by the US FDA in 1985. The approved use of this drug in reducing the side effects caused by chemotherapy of cancer patients such as anorexia, nausea, pain and vomiting, as well as its use in the treatment of weight loss in AIDS patients has also been approved in 1992.Methods: In this article, while referring to a summary of the history of medicinal cannabis, we review Marinol. Also, investigation and understanding of how herbal cannabinoids helps the endocannabinoid system, which is responsible for the health balance (Homeostasis) of the body, has been taken into consideration. In this work, the necessary operations have been carried out, from seed germination to the preparation of medicine (vegetable Marinol) and the preparation of capsules. Monitoring and analysis of cannabinoids was done by a gas chromatography device connected to a mass spectrometer (GC/Mass Spectroscopy).Results: The efficiency of the resin in the flower was 38%, which was obtained at the optimum point of 97.5% of THC and 2.5% of cannabinoids, and the main part was cannabinol, and thus the percentage of the effective substance in the plant was 37.05%. After dissolving the solvent at room temperature, we will dissolve the obtained resin in sesame oil and in this way, we will be able to encapsulate different doses of vegetable Marinol.Conclusion: The idea of using plant Marinol (cannabis flower extract (resin)) with high THC in pure sesame oil instead of synthetic dronabinol (chemical cannabinol) can be derived from less side effects, higher therapeutic effect, less persistence in the body and cheaper price. It is related to the chemical type of this drug.
